The incorporation of labeled palmitic acid into the phospholipids of normal and fatty livers.

نویسندگان

  • J L GLENN
  • E OPALKA
  • K TISCHER
چکیده

It has been previously demonstrated that the administration of cerium to female rats resulted in a 2to 3-fold increase in hepatic lipid (2). The increase of lipid in this type of fatty liver was shown to be due to an elevation of triglyceride, whereas phospholipid content remained normal (3). An additional finding was a pronounced elevation of plasma free fatty acids after the injection of this rare earth (4). Numerous investigators have often suggested that phospholipids play a role in maintaining a normal lipid content in the liver, although the metabolism of these compounds was reported to decrease (5) as well as increase (6) under conditions when the liver was accumulating lipid. The present study was designed to follow the incorporation of a metabolically active fatty acid, palmitic acid-l-C14, into the individual phospholipids of liver in normal animals and in animals undergoing fatty degeneration of hepatic tissue.

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عنوان ژورنال:
  • The Journal of biological chemistry

دوره 238  شماره 

صفحات  -

تاریخ انتشار 1963